|Other Names||Thrombospondin-1, THBS1, TSP, TSP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8522a was selected from the N-term region of human THBS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).|
|Cellular Location||Endoplasmic reticulum. Sarcoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
THBS1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis,and tumorigenesis.
Hofsteenge,J., et.al., J. Biol. Chem. 276 (9), 6485-6498 (2001)Roszmusz,E., et.al., Biochem. Biophys. Res. Commun. 296 (1), 156-160 (2002)
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