|Other Names||NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4, Complex I-B15, CI-B15, NADH-ubiquinone oxidoreductase B15 subunit, NDUFB4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8525b was selected from the C-term region of human NDUFB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein; Matrix side|
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Provided below are standard protocols that you may find useful for product applications.
NDUFB4 is a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone.
Ma,J., et.al., Atherosclerosis 191 (1), 63-72 (2007)Loeffen,J.L., et.al., Biochem. Biophys. Res. Commun. 253 (2), 415-422 (1998)Mao,M., et,al., Proc. Natl. Acad. Sci. U.S.A. 95 (14), 8175-8180 (1998)
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