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IL1B Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01584
Clone Names 90625104
Peptide ID 90625104
Additional Information
Gene ID 3553
Other Names Interleukin-1 beta, IL-1 beta, Catabolin, IL1B, IL1F2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8531c was selected from the Center region of human IL1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL1B
Synonyms IL1F2
Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Cellular Location Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins
Research Areas
Citations (0)

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IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.


Yu,J.,, Am. J. Gastroenterol. (2009)Ito,A.,, J. Biol. Chem. 271 (25), 14657-14660 (1996)

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$ 80.00
Cat# BP8531c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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