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PTPN4 Antibody (Center R519) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P29074 |
|---|---|
| Clone Names | 80917166 |
| Gene ID | 5775 |
|---|---|
| Other Names | Tyrosine-protein phosphatase non-receptor type 4, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1, PTPN4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8543c was selected from the Center region of human PTPN4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTPN4 |
|---|---|
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton. |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPN4 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
References
Young,J.A., et.al., Mol. Immunol. 45 (14), 3756-3766 (2008)Stelzl,U., et.al., Cell 122 (6), 957-968 (2005)Hironaka,K., et.al., J. Biol. Chem. 275 (21), 16167-16173 (2000)
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