|Other Names||Carbonyl reductase [NADPH] 3, NADPH-dependent carbonyl reductase 3, CBR3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8544c was selected from the Center region of human CBR3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).|
|Tissue Location||Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
Persson,B., et.al., Chem. Biol. Interact. 178 (1-3), 94-98 (2009)Umemoto,M., et.al., Br. J. Cancer 85 (7), 1032-1036 (2001)
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