|Other Names||Vacuolar protein sorting-associated protein 53 homolog, VPS53|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8546a was selected from the N-term region of human VPS53. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
VPS53 is a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi.
Ko,J.K., et.al., J. Cell. Sci. 120 (PT 16), 2912-2923 (2007)Zhu,J.D., et.al., Cell Res. 16 (9), 780-796 (2006)
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