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C10orf59 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5VYX0
Clone Names 90723019
Peptide ID 90723019
Additional Information
Gene ID 55328
Other Names Renalase, Monoamine oxidase-C, MAO-C, alpha-NAD(P)H oxidase/anomerase, RNLS, C10orf59
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8552c was selected from the Center region of human C10orf59. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C10orf59
Function Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Cellular Location Secreted.
Tissue Location Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
Research Areas
Citations (0)

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Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk.


Zhao,Q.,, J. Mol. Med. 85 (8), 877-885 (2007)Xu,, Curr. Opin. Nephrol. Hypertens. 16 (4), 373-378 (2007)

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$ 80.00
Cat# BP8552c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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