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PIGR Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P01833
Clone Names 90723230
Peptide ID 90723230
Additional Information
Gene ID 5284
Other Names Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, Secretory component, PIGR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8555b was selected from the C-term region of human PIGR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIGR
Function This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

PIGR binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

References

Ewing,R.M., et.al., Mol. Syst. Biol. 3, 89 (2007)Orzech,E., Cohen,S., et.al., J. Biol. Chem. 275 (20), 15207-15219 (2000)

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$ 80.00
Cat# BP8555b
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