|Other Names||Gasdermin-B, Gasdermin-like protein, GSDMB, GSDML|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8559c was selected from the Center region of human GSDMB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells.|
|Cellular Location||Cytoplasm. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells|
|Tissue Location||Expressed in gastric, liver and colon cell lines, carcinomas and non-lesional tissues|
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Provided below are standard protocols that you may find useful for product applications.
GSDMB is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.
Hur,J.W., et.al., Rheumatol. Int. 28 (8), 783-789 (2008)Chen,M.J., et.al., Nucleic Acids Res. 35 (8), 2682-2694 (2007)
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