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CNTN6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UQ52 |
|---|---|
| Clone Names | 90904117 |
| Gene ID | 27255 |
|---|---|
| Other Names | Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8561c was selected from the Center region of human CNTN6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CNTN6 |
|---|---|
| Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
| Tissue Location | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CNTN6 is a member of the immunoglobulin superfamily. It is a cosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
References
Manderson,E.N., et.al., Int. J. Gynecol. Cancer 19 (4), 513-525 (2009)
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