|Other Names||Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8561c was selected from the Center region of human CNTN6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
CNTN6 is a member of the immunoglobulin superfamily. It is a cosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
Manderson,E.N., et.al., Int. J. Gynecol. Cancer 19 (4), 513-525 (2009)
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