|Other Names||Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa, CP110, Cep110, CCP110, CEP110, CP110, KIAA0419|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8565c was selected from the Center region of human CP110. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CEP110, CP110, KIAA0419|
|Function||Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis|
|Tissue Location||Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
CP110 is necessary for centrosome duplication. This protein collaborates with CEP97, being involved in the suppression of a cilia assembly program. It is required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Spektor,A., et.al., Cell 130 (4), 678-690 (2007)Chen,Z., et.al., Dev. Cell 3 (3), 339-350 (2002)
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