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TOB1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P50616
Clone Names 80924255
Peptide ID 80924255
Additional Information
Gene ID 10140
Other Names Protein Tob1, Transducer of erbB-2 1, TOB1, TOB, TROB1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8571a was selected from the N-term region of human TOB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOB1
Synonyms TOB, TROB1
Function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex.
Cellular Location Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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TOB1 is a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.


Suzuki,T.,, Genes Dev. 16 (11), 1356-1370 (2002)Yoshida,Y.,, Cell 103 (7), 1085-1097 (2000)

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$ 80.00
Cat# BP8571a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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