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UBTF Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P17480 |
|---|---|
| Clone Names | 80924266 |
| Gene ID | 7343 |
|---|---|
| Other Names | Nucleolar transcription factor 1, Autoantigen NOR-90, Upstream-binding factor 1, UBF-1, UBTF, UBF, UBF1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8572a was selected from the N-term region of human UBTF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UBTF |
|---|---|
| Synonyms | UBF, UBF1 |
| Function | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. |
| Cellular Location | Nucleus, nucleolus {ECO:0000250|UniProtKB:P25976} |
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Provided below are standard protocols that you may find useful for product applications.
Background
UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes.
References
Hempel,W.M., et.al., Mol. Cell. Biol. 16 (2), 557-563 (1996)Voit,R., et.al., Nucleic Acids Res. 23 (14), 2593-2599 (1995)
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