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C5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01031
Clone Names 90713020
Peptide ID 90713020
Additional Information
Gene ID 727
Other Names Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5 beta chain, Complement C5 alpha chain, C5a anaphylatoxin, Complement C5 alpha' chain, C5, CPAMD4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8577a was selected from the N-term region of human C5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name C5
Synonyms CPAMD4
Function Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Cellular Location Secreted.
Research Areas
Citations (0)

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C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.


McClure,A.,, Rheumatology (Oxford) 48 (11), 1369-1374 (2009)DiScipio,, J. Biol. Chem. 267 (24), 17087-17094 (1992)

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$ 80.00
Cat# BP8577a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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