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ABCC5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O15440
Clone Names 90819015
Peptide ID 90819015
Additional Information
Gene ID 10057
Other Names Multidrug resistance-associated protein 5, ATP-binding cassette sub-family C member 5, Multi-specific organic anion transporter C, MOAT-C, SMRP, pABC11, ABCC5, MRP5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8578c was selected from the Center region of human ABCC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCC5
Synonyms MRP5
Function Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location All isoforms are equally expressed in retina.
Research Areas
Citations (0)

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ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.


Olsen,J.V.,, Cell 127 (3), 635-648 (2006)

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$ 80.00
Cat# BP8578c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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