|Other Names||Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E, ANO5, GDD1, TMEM16E|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8580b was selected from the C-term region of human ANO5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Does not exhibit calcium-activated chloride channel (CaCC) activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane. Note=Colocalized with CALR/calreticulin. Shows an intracellular localization according to PubMed:22075693|
|Tissue Location||Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells.|
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Provided below are standard protocols that you may find useful for product applications.
ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel.
Katoh,M. et.al., Am. J. Hum. Genet. 75 (5), 927-928 (2004)Tsutsumi,S., et.al., Am. J. Hum. Genet. 74 (6), 1255-1261 (2004)
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