|Other Names||Prostaglandin E synthase, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein, PTGES, MGST1L1, MPGES1, PGES, PIG12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8589a was selected from the N-term region of human PTGES. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MGST1L1, MPGES1, PGES, PIG12|
|Function||Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PTGES is a glutathione-dependent prostaglandin E synthase. The expression of it has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that it may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
Mattila,S.,et.al.,Neuropathology 29 (2), 156-165 (2009)Menon,R.,et.al., Reprod. Biol. Endocrinol. 7, 62 (2009)Jakobsson,P.J.,et.al.,Protein Sci. 8 (3), 689-692 (1999)
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