|Other Names||Elastin, Tropoelastin, ELN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8594c was selected from the Center region of human ELN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.|
|Tissue Location||Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin|
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Provided below are standard protocols that you may find useful for product applications.
ELN is one of the two components of elastic fibers. This protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues.
Bertram,C.et.al., Mech. Ageing Dev. 130 (10), 657-669 (2009)Wakui,H., et.al., Ren. Physiol. Biochem. 15 (1), 1-9 (1992)
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