FCGR3B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75015 |
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Clone Names | 90713062 |
Gene ID | 2215 |
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Other Names | Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8628c was selected from the Center region of human FCGR3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FCGR3B |
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Synonyms | CD16B, FCG3, FCGR3, IGFR3 |
Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted Note=Secreted after cleavage |
Tissue Location | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils |
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Provided below are standard protocols that you may find useful for product applications.
Background
FCGR3B is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. It binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. It may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
References
Gessner,J.E., et.al., J. Biol. Chem. 270 (3), 1350-1361 (1995)Ho,Y.P., et.al., J. Clin. Periodontol. (2009)
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