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FCGR3B Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75015
Clone Names 90713062
Peptide ID 90713062
Additional Information
Gene ID 2215
Other Names Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8628c was selected from the Center region of human FCGR3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCGR3B
Synonyms CD16B, FCG3, FCGR3, IGFR3
Function Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage
Tissue Location Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils
Research Areas
Citations (0)

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Background

FCGR3B is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. It binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. It may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

References

Gessner,J.E., et.al., J. Biol. Chem. 270 (3), 1350-1361 (1995)Ho,Y.P., et.al., J. Clin. Periodontol. (2009)

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$ 80.00
Cat# BP8628c
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