|Other Names||Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8628c was selected from the Center region of human FCGR3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD16B, FCG3, FCGR3, IGFR3|
|Function||Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage|
|Tissue Location||Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils|
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Provided below are standard protocols that you may find useful for product applications.
FCGR3B is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. It binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. It may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Gessner,J.E., et.al., J. Biol. Chem. 270 (3), 1350-1361 (1995)Ho,Y.P., et.al., J. Clin. Periodontol. (2009)
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