|Other Names||COMM domain-containing protein 3, Protein Bup, Protein PIL, COMMD3, BUP, C10orf8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8640c was selected from the Center region of human COMMD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed with highest expression in thymus.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
COMMD proteins, a novel family of structural and functional homologs of MURR1.
Burstein,E., et.al., J. Biol. Chem. 280 (23), 22222-22232 (2005)
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