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COMMD3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UBI1
Clone Names 90904132
Peptide ID 90904132
Additional Information
Other Names COMM domain-containing protein 3, Protein Bup, Protein PIL, COMMD3, BUP, C10orf8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8640c was selected from the Center region of human COMMD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name COMMD3
Synonyms BUP, C10orf8
Function May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed with highest expression in thymus. EMBL; AY542159; AAS22241.1; -; mRNA EMBL; AF201948; AAF17240.1; -; mRNA EMBL; AF078848; AAD44480.1; -; mRNA EMBL; AL158211; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471072; EAW86149.1; -; Genomic_DNA EMBL; CH471072; EAW86155.1; -; Genomic_DNA EMBL; BC022898; AAH22898.1; -; mRNA CCDS; CCDS7137.1; - RefSeq; NP_036203.1; NM_012071.3 UniGene; Hs.534398; - ProteinModelPortal; Q9UBI1; - BioGrid; 116984; 39 CORUM; Q9UBI1; - IntAct; Q9UBI1; 12 MINT; Q9UBI1; - STRING; 9606.ENSP00000366032; - iPTMnet; Q9UBI1; - PhosphoSitePlus; Q9UBI1; - BioMuta; COMMD3; - DMDM; 51316114; - EPD; Q9UBI1; - MaxQB; Q9UBI1; - PaxDb; Q9UBI1; - PeptideAtlas; Q9UBI1; - PRIDE; Q9UBI1; - ProteomicsDB; 83972; - TopDownProteomics; Q9UBI1; - DNASU; 23412; - Ensembl; ENST00000376836; ENSP00000366032; ENSG00000148444 GeneID; 23412; - KEGG; hsa:23412; - UCSC; uc001irf.4; human CTD; 23412; - DisGeNET; 23412; - EuPathDB; HostDB:ENSG00000148444.15; - GeneCards; COMMD3; - HGNC; HGNC:23332; COMMD3 HPA; HPA036584; - MIM; 616700; gene neXtProt; NX_Q9UBI1; - OpenTargets; ENSG00000148444; - PharmGKB; PA134864927; - eggNOG; ENOG410IKHX; Eukaryota eggNOG; ENOG4111PD7; LUCA GeneTree; ENSGT00390000015971; - HOGENOM; HOG000231902; - HOVERGEN; HBG051068; - InParanoid; Q9UBI1; - KO; K22559; - OMA; NQLHKMY; - OrthoDB; EOG091G0O9G; - PhylomeDB; Q9UBI1; - TreeFam; TF329267; - Reactome; R-HSA-6798695; Neutrophil degranulation Reactome; R-HSA-8951664; Neddylation ChiTaRS; COMMD3; human GenomeRNAi; 23412; - PRO; PR:Q9UBI1; - Proteomes; UP000005640; Chromosome 10 Bgee; ENSG00000148444; - CleanEx; HS_COMMD3; - ExpressionAtlas; Q9UBI1; baseline and differential Genevisible; Q9UBI1; HS GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR017920; COMM InterPro; IPR037355; COMMD3 PANTHER; PTHR31159; PTHR31159; 1 Pfam; PF07258; COMM_domain; 1 PROSITE; PS51269; COMM; 1 1: Evidence at protein level; Complete proteome; Cytoplasm; Ion transport; Nucleus; Polymorphism; Reference proteome; Sodium; Sodium transport; Transcription; Transcription regulation; Transport; Ubl conjugation pathway CHAIN 1 195 COMM domain-containing protein 3 /FTId=PRO_0000077389 DOMAIN 124 193 COMM. {ECO:0000255|PROSITE- ProRule:PRU00602} VARIANT 18 18 R -> G (in dbSNP:rs11552445) /FTId=VAR_061121 SEQUENCE 195 AA; 22151 MW; AC757941FC17F757 CRC64; MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL VTLSVQNTDS PSYPEISFSC SMEQLQDLVG KLKDASKSLE RATQL
Research Areas
Citations (0)

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Background

COMMD proteins, a novel family of structural and functional homologs of MURR1.

References

Burstein,E., et.al., J. Biol. Chem. 280 (23), 22222-22232 (2005)

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$ 80.00
Cat# BP8640c
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