|Other Names||COMM domain-containing protein 3, Protein Bup, Protein PIL, COMMD3, BUP, C10orf8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8640c was selected from the Center region of human COMMD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed with highest expression in thymus.|
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Provided below are standard protocols that you may find useful for product applications.
COMMD proteins, a novel family of structural and functional homologs of MURR1.
Burstein,E., et.al., J. Biol. Chem. 280 (23), 22222-22232 (2005)
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