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CYP2E1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P05181
Clone Names 80311106
Peptide ID 80311106
Additional Information
Gene ID 1571
Other Names Cytochrome P450 2E1, 11413-, 4-nitrophenol 2-hydroxylase, 11413n7, CYPIIE1, Cytochrome P450-J, Cytochrome P450 2E1, N-terminally processed, CYP2E1, CYP2E
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8644b was selected from the C-term region of human CYP2E1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP2E1
Synonyms CYP2E
Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Research Areas
Citations (0)

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Background

CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

References

Mingazova,S.R., et.al., Med Tr Prom Ekol 11, 30-33 (2009)Robinson,R.C., et.al., Pharmacology 39 (3), 137-144 (1989)

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$ 80.00
Cat# BP8644b
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