|Other Names||Neural cell adhesion molecule L1-like protein, Close homolog of L1, Processed neural cell adhesion molecule L1-like protein, CHL1, CALL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8662c was selected from the Center region of human CHL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Soluble forms produced by cleavage/shedding also exist.|
|Tissue Location||Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.|
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Provided below are standard protocols that you may find useful for product applications.
CHL1 is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways.
Sakurai,K., et.al., Mol. Psychiatry 7 (4), 412-415 (2002)Angeloni,D., et.al., Am. J. Med. Genet. 86 (5), 482-485 (1999)
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