|Other Names||Microtubule-associated protein 6, MAP-6, Stable tubule-only polypeptide, STOP, MAP6, KIAA1878|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8670c was selected from the Center region of human MAP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.|
|Cellular Location||Cytoplasm, cytoskeleton. Golgi apparatus Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS)|
|Tissue Location||Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study)|
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Provided below are standard protocols that you may find useful for product applications.
MAP6 is a microtubule-associated protein. This protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization.
Andrieux,A., et.al., Genes Dev. 16 (18), 2350-2364 (2002)Bosc,C., et.al., Biochemistry 42 (42), 12125-12132 (2003)
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