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TSPAN12 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95859
Clone Names 90909142
Peptide ID 90909142
Additional Information
Gene ID 23554
Other Names Tetraspanin-12, Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12, TSPAN12, NET2, TM4SF12
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8693b was selected from the C-term region of human TSPAN12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSPAN12
Synonyms NET2, TM4SF12
Function Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.


Xu,D.,, FASEB J. 23 (11), 3674-3681 (2009)Berditchevski,, J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)

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$ 80.00
Cat# BP8693b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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