|Other Names||Short-chain specific acyl-CoA dehydrogenase, mitochondrial, SCAD, Butyryl-CoA dehydrogenase, ACADS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8712b was selected from the C-term region of human ACADS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
ACADS is a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency.
Naito,E., et.al., J. Clin. Invest. 85 (5), 1575-1582 (1990)Vanhove,G., et.al., Biochem. J. 292 (PT 1), 23-30 (1993)
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