|Other Names||Testicular acid phosphatase, ACPT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8714a was selected from the N-term region of human ACPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. ACPT has structural similarity to prostatic and lysosomal acid phosphatases.
Fleisig,H., et.al., Neuroscience 127 (1), 91-100 (2004)
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