|Other Names||Cholesterol 24-hydroxylase, CH24H, Cytochrome P450 46A1, CYP46A1, CYP46|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8726c was selected from the Center region of human CYP46A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein|
|Tissue Location||Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age|
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Provided below are standard protocols that you may find useful for product applications.
CYP46A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Bogdanovic,N., et.al., Neurosci. Lett. 314 (1-2), 45-48 (2001)Bjorkhem,I., et.al., J. Lipid Res. 39 (8), 1594-1600 (1998)
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