|Other Names||B1 bradykinin receptor, B1R, BK-1 receptor, BDKRB1, BRADYB1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8735c was selected from the Center region of human BDKRB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. BDKRB1 is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
Bachvarov,D.R., et.al., Genomics 33 (3), 374-381 (1996)
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