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TIRAP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P58753
Clone Names 90713208
Peptide ID 90713208
Additional Information
Gene ID 114609
Other Names Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2, TIRAP, MAL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8759b was selected from the C-term region of human TIRAP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAL
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Cellular Location Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane
Tissue Location Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain
Research Areas
Citations (0)

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Adapter involved in the TLR4 signaling pathway in the innate immune response. TIRAP acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.


Eto,A.,, Biochem. Biophys. Res. Commun. 301 (2), 495-501 (2003)

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$ 80.00
Cat# BP8759b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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