|Other Names||ATP-dependent RNA helicase DDX50, DEAD box protein 50, Gu-beta, Nucleolar protein Gu2, DDX50|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8763a was selected from the N-term region of human DDX50. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
DDX50 belongs to the RNA helicase family of proteins involved in unwinding double-stranded RNA during transcription and pre-mRNA splicing, ribosomal RNA synthesis, translation, RNA transport, and RNA stability and degradation. RNA helicases have an Asp-Glu-Ala-Asp (DEAD) motif within the catalytic domain, which gives the family its name (Valdez et al., 2002).
Dephoure N., et.al., Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).Scherl A.,et.al., Mol. Biol. Cell 13:4100-4109(2002).
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