DCT Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P40126 |
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Clone Names | 90921084 |
Gene ID | 1638 |
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Other Names | L-dopachrome tautomerase, DCT, DT, L-dopachrome Delta-isomerase, Tyrosinase-related protein 2, TRP-2, TRP2, DCT, TYRP2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8771a was selected from the N-term region of human DCT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DCT (HGNC:2709) |
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Synonyms | TYRP2 |
Function | Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2- carboxylic acid (DHICA). |
Cellular Location | Melanosome membrane; Single-pass type I membrane protein. Melanosome {ECO:0000250|UniProtKB:P29812}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38 {ECO:0000250|UniProtKB:P29812} |
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Provided below are standard protocols that you may find useful for product applications.
Background
DCT is involved in regulating eumelanin and phaeomelanin levels.
References
Nishihira,J., et.al., Biochem. Biophys. Res. Commun. 243 (2), 538-544 (1998)
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