|Other Names||2', 3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPase, CNP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8791c was selected from the Center region of human CNP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|
|Cellular Location||Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.
Sprinkle,T.J., et.al., Genomics 13 (3), 877-880 (1992)
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