|Other Names||Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8792a was selected from the N-term region of human GCDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Isoform 1 and isoform 2 are expressed in fibroblasts and liver|
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Provided below are standard protocols that you may find useful for product applications.
GCDH catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
Keyser B., et.al., Hum. Mol. Genet. 17:3854-3863(2008).Anikster Y., et.al., Am. J. Hum. Genet. 59:1012-1018(1996).
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