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GCDH Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92947 |
|---|---|
| Clone Names | 90121133 |
| Gene ID | 2639 |
|---|---|
| Other Names | Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8792a was selected from the N-term region of human GCDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GCDH |
|---|---|
| Function | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Isoform Long and isoform Short are expressed in fibroblasts and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
GCDH catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
References
Keyser B., et.al., Hum. Mol. Genet. 17:3854-3863(2008).Anikster Y., et.al., Am. J. Hum. Genet. 59:1012-1018(1996).
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