|Other Names||Bridging integrator 3, BIN3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8794a was selected from the N-term region of human BIN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytokinesis and septation where it has a role in the localization of F-actin.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Ubiquitously expressed except in brain.|
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Provided below are standard protocols that you may find useful for product applications.
BIN3 is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.
Ren,G., et.al., Microbiol. Mol. Biol. Rev. 70 (1), 37-120 (2006)
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