|Other Names||Disintegrin and metalloproteinase domain-containing protein 30, ADAM 30, 3424-, ADAM30|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8805b was selected from the C-term region of human ADAM30. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).|
|Cellular Location||Late endosome membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762)|
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Provided below are standard protocols that you may find useful for product applications.
ADAM30 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
Hu,C., et.al., PLoS ONE 4 (10), E7643 (2009)
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