|Other Names||Spindlin-1, Ovarian cancer-related protein, Spindlin1, SPIN1, OCR, SPIN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8827a was selected from the N-term region of human SPIN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.|
|Cellular Location||Nucleus. Nucleus, nucleolus.|
|Tissue Location||Highly expressed in ovarian cancer tissues.|
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Provided below are standard protocols that you may find useful for product applications.
SPIN1 may play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).
Gao,Y., et.al., Biochem. Biophys. Res. Commun. 335 (2), 343-350 (2005)Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
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