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SPIN1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y657
Other Accession NP_006708
Clone Names 91023162
Peptide ID 91023162
Additional Information
Gene ID 10927
Other Names Spindlin-1, Ovarian cancer-related protein, Spindlin1, SPIN1, OCR, SPIN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8827a was selected from the N-term region of human SPIN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPIN1
Synonyms OCR, SPIN
Function Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Cellular Location Nucleus. Nucleus, nucleolus.
Tissue Location Highly expressed in ovarian cancer tissues.
Research Areas
Citations (0)

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SPIN1 may play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).


Gao,Y.,, Biochem. Biophys. Res. Commun. 335 (2), 343-350 (2005)Olsen,J.V.,, Cell 127 (3), 635-648 (2006)

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$ 80.00
Cat# BP8827a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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