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UBAP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZ09 |
|---|---|
| Other Accession | NP_057609 |
| Clone Names | 91023163 |
| Gene ID | 51271 |
|---|---|
| Other Names | Ubiquitin-associated protein 1, UBAP-1, Nasopharyngeal carcinoma-associated gene 20 protein, UBAP1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8828a was selected from the N-term region of human UBAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UBAP1 {ECO:0000303|PubMed:11599797, ECO:0000312|HGNC:HGNC:12461} |
|---|---|
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368). |
| Cellular Location | Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic (PubMed:21757351). Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351). |
| Tissue Location | Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
UBAP1 is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein riginates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas.
References
Qian,J., et.al., J. Cancer Res. Clin. Oncol. 127 (10), 613-618 (2001)Qian,J., et.al., Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 33 (2), 147-152 (2001)
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