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PISD Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
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- BACKGROUND
| Primary Accession | Q9UG56 |
|---|---|
| Other Accession | NP_055153 |
| Clone Names | 91023165 |
| Gene ID | 23761 |
|---|---|
| Other Names | Phosphatidylserine decarboxylase proenzyme, Phosphatidylserine decarboxylase alpha chain, Phosphatidylserine decarboxylase beta chain, PISD |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8829c was selected from the Center region of human PISD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PISD {ECO:0000255|HAMAP-Rule:MF_03208} |
|---|---|
| Function | Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). |
| Cellular Location | [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:30858161, ECO:0000305|PubMed:33718843}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208} [Isoform 1]: Mitochondrion inner membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphatidylserine decarboxylases catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits
References
Simpson,J.C., et.al., EMBO Rep. 1 (3), 287-292 (2000)
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