|Other Names||Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8836b was selected from the C-term region of human IRF4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).|
|Tissue Location||Lymphoid cells.|
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Provided below are standard protocols that you may find useful for product applications.
IRF4 is a transcriptional activator. It Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter and binds the immunoglobulin lambda light chain enhancer, together with PU.1. This protein probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
Iida,S., Rao,P.H., et.al., Nat. Genet. 17 (2), 226-230 (1997)
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