IRF4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15306 |
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Clone Names | 80522030 |
Gene ID | 3662 |
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Other Names | Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8836b was selected from the C-term region of human IRF4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IRF4 |
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Synonyms | MUM1 |
Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Lymphoid cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IRF4 is a transcriptional activator. It Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter and binds the immunoglobulin lambda light chain enhancer, together with PU.1. This protein probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
References
Iida,S., Rao,P.H., et.al., Nat. Genet. 17 (2), 226-230 (1997)
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