|Other Names||Argininosuccinate lyase, ASAL, Arginosuccinase, ASL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8837a was selected from the N-term region of human ASL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
ASL is a member of the lyase 1 family. This protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle.
Barbosa,P., et.al., J. Biol. Chem. 266 (8), 5286-5290 (1991)Linnebank,M., et.al., Hum. Genet. 111 (4-5), 350-359 (2002)
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