|Other Names||Ras-related C3 botulinum toxin substrate 2, GX, Small G protein, p21-Rac2, RAC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8839b was selected from the C-term region of human RAC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.|
|Cellular Location||Cytoplasm. Note=Membrane-associated when activated|
|Tissue Location||Hematopoietic specific.|
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Provided below are standard protocols that you may find useful for product applications.
RAC2 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
Reibel,L., et.al., Biochem. Biophys. Res. Commun. 175 (2), 451-458 (1991)Brechard,S., et.al., J. Leukoc. Biol. 85 (4), 638-647 (2009)
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