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MFN2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95140
Clone Names 90504004
Peptide ID 90504004
Additional Information
Gene ID 9927
Other Names Mitofusin-2, 365-, Transmembrane GTPase MFN2, MFN2, CPRP1, KIAA0214
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8840c was selected from the Center region of human MFN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFN2
Synonyms CPRP1, KIAA0214
Function Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Cellular Location Mitochondrion outer membrane; Multi- pass membrane protein. Note=Colocalizes with BAX during apoptosis
Tissue Location Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Research Areas
Citations (0)

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MFN2 is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system.


Calvo,J.,,Arch. Neurol. 66 (12), 1511-1516 (2009)

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$ 80.00
Cat# BP8840c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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