PLCL1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15111 |
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Clone Names | 90805084 |
Gene ID | 5334 |
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Other Names | Inactive phospholipase C-like protein 1, PLC-L1, Phospholipase C-deleted in lung carcinoma, Phospholipase C-related but catalytically inactive protein, PRIP, PLCL1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8850a was selected from the N-term region of human PLCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLCL1 |
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Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PLCL1 is an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and sphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a nhibitor of PPP1C.
References
Liu,Y.Z., et.al., PLoS ONE 3 (9), E3160 (2008)
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