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AMOTL2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y2J4
Clone Names 90819107
Peptide ID 90819107
Additional Information
Gene ID 51421
Other Names Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8860c was selected from the Center region of human AMOTL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMOTL2
Synonyms KIAA0989
Function Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Cellular Location Recycling endosome.
Research Areas
Citations (0)

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Background

AMOTL2 is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

References

Bratt,A.,et.al., Gene 298 (1), 69-77 (2002)

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$ 80.00
Cat# BP8860c
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