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PEX13 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92968 |
|---|---|
| Clone Names | 90909087 |
| Gene ID | 5194 |
|---|---|
| Other Names | Peroxisomal membrane protein PEX13, Peroxin-13, PEX13 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8861c was selected from the Center region of human PEX13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PEX13 {ECO:0000303|PubMed:9653144, ECO:0000312|HGNC:HGNC:8855} |
|---|---|
| Function | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:8858165, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:9653144, PubMed:8858165, PubMed:28765278). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:9653144, PubMed:8858165). |
| Cellular Location | Peroxisome membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
PEX13 is encoding a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm.
References
Al-Dirbashi,O.Y.,et.al., Am. J. Med. Genet. A 149A (6), 1219-1223 (2009)
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