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APTX Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q7Z2E3
Clone Names 90819136
Peptide ID 90819136
Additional Information
Gene ID 54840
Other Names Aprataxin, 3---, Forkhead-associated domain histidine triad-like protein, FHA-HIT, APTX, AXA1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8863c was selected from the Center region of human APTX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AXA1
Function DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non- ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
Cellular Location Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization
Tissue Location Widely expressed. In brain, it is expressed in the posterior cortex, cerebellum, hippocampus and olfactory bulb Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2.
Research Areas
Citations (0)

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APTX is encoding a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair.


Luedeke,M.,, Cancer Epidemiol. Biomarkers Prev. 18 (11), 3030-3035 (2009)

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$ 80.00
Cat# BP8863c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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