|Other Names||Bisphosphoglycerate mutase, BPGM, 3-bisphosphoglycerate mutase, erythrocyte, 3-bisphosphoglycerate synthase, 3-diphosphoglycerate mutase, DPGM, BPG-dependent PGAM, BPGM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8864c was selected from the Center region of human BPGM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 18.104.22.168) activity.|
|Tissue Location||Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto- maternal interface (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
BPGM is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This protein encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity.
Wang,Y., et.al., J. Biol. Chem. 281 (51), 39642-39648 (2006)
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