DTX4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y2E6 |
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Clone Names | 90921145 |
Gene ID | 23220 |
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Other Names | E3 ubiquitin-protein ligase DTX4, 632-, Protein deltex-4, Deltex4, RING finger protein 155, DTX4, KIAA0937, RNF155 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8872a was selected from the N-term region of human DTX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DTX4 |
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Synonyms | KIAA0937, RNF155 |
Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations
References
Storck,S.,et.al., Mol. Cell. Biol. 25 (4), 1437-1445 (2005)
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