|Other Names||E3 ubiquitin-protein ligase DTX4, 632-, Protein deltex-4, Deltex4, RING finger protein 155, DTX4, KIAA0937, RNF155|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8872a was selected from the N-term region of human DTX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.|
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Provided below are standard protocols that you may find useful for product applications.
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations
Storck,S.,et.al., Mol. Cell. Biol. 25 (4), 1437-1445 (2005)
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