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RGS4 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P49798
Clone Names 90504145
Peptide ID 90504145
Additional Information
Gene ID 5999
Other Names Regulator of G-protein signaling 4, RGP4, RGS4, RGS4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8879c was selected from the Center region of human RGS4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS4
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Tissue Location Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum
Research Areas
Citations (0)

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Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.


Heximer,S.P.,, Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14389-14393 (1997)

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$ 80.00
Cat# BP8879c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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