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TP73 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O15350
Clone Names 90625247
Peptide ID 90625247
Additional Information
Gene ID 7161
Other Names Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8881c was selected from the Center region of human TP73. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP73
Synonyms P73
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Cellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
Tissue Location Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue
Research Areas
Citations (0)

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TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.


Mai,M.,, Genomics 51 (3), 359-363 (1998)Mai,M.,, Oncogene 17 (13), 1739-1741 (1998)

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$ 80.00
Cat# BP8881c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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